Improved GCxGC-TOFMS Workflow to More Efficiently Meet Compliance and Confidence Requirements for Fragrance Allergen Analysis

To meet the need of a fast, robust, and reliable--but also sufficiently flexible--method to quantify fragrance allergens, an analytical workflow based on comprehensive two-dimensional gas chromatography (GCxGC) coupled to time-of-flight mass spectrometry (TOFMS) was developed. In this work, the analysis of 57 fragrance allergens and their relevant isomers is demonstrated with the LECO Pegasus BTX 4D with QuadJet Thermal Modulator.