Improved GCxGC-TOFMS Workflow to More Efficiently Meet Compliance and Confidence Requirements for Fragrance Allergen Analysis

This application note presents an improved workflow for the analysis of fragrance allergens using comprehensive two-dimensional gas chromatography (GC×GC) coupled with time-of-flight mass spectrometry (TOFMS). With increasing regulatory pressure on labeling and quantifying fragrance allergens in personal care and consumer products, sensitive and robust analytical methods are essential. The study demonstrates how GC×GC-TOFMS, in combination with ChromaTOF software, enhances compound separation, identification, and quantitation. The optimized workflow streamlines data processing while maintaining analytical precision and repeatability. Key examples highlight the detection of regulated fragrance allergens in complex mixtures, showcasing how the method supports both compliance with EU cosmetic regulations and in-depth formulation analysis. This approach is ideal for R&D and QA/QC labs focused on allergen control and product safety.