Comprehensive Analysis of Drug Residues from a Confiscated Pipe: GC-High Resolution Mass Spectrometry with Chemical Ionization to Facilitate Unknown Identification

This application note demonstrates the use of high-resolution gas chromatography-time-of-flight mass spectrometry (GC-HRT) with chemical ionization (CI) to identify unknown drug residues from a confiscated pipe. The study highlights the advantages of CI in preserving molecular ions, aiding in the structural elucidation of synthetic cannabinoids and other illicit substances. By employing accurate mass measurements, the analysis successfully identified compounds such as AM-2201 and Δ9-THC, showcasing the effectiveness of GC-HRT with CI in forensic investigations